Monitor patients with any degree of hepatic disease carefully. Bupropion undergoes extensive hepatic metabolism and excretion in the urine as metabolites; there is a risk for accumulation in hepatic impairment. In addition, caution is advisable when using bupropion in patients with severe hepatic impairment because this condition can increase the risk of seizures. Forfivo XL, a mg extended-release tablet formulation of bupropion, is not recommended in patients with renal impairment since a lower dosage strength is not available for use in this patient population.
Other bupropion products should be used with extreme caution in patients with renal disease or renal failure because the parent compound or active metabolites could accumulate.
Consider reduced dosages in these patient populations based on the degree of organ impairment, and closely monitor for adverse reactions that could indicate high drug or metabolite levels. Rarely, bupropion may cause a fast or irregular heart beat or increases in blood pressure in some patients. It should be used with caution in patients with a recent history of acute myocardial infarction or unstable cardiac disease, including heart failure. Pharmacokinetic studies suggest that left ventricular dysfunction results in lowered metabolism and excretion of bupropion and its metabolites.
Because treatment with bupropion can result in elevated blood pressure and hypertension, patients should have their blood pressure checked prior to bupropion initiation and periodically throughout treatment. Bupropion may be used in combination with nicotine transdermal systems NTS as an aide to smoking cessation. In clinical trials, new onset treatment-induced hypertension or exacerbation of existing high blood pressure occurred more commonly in patients using the combination bupropion-NTS therapy.
In some cases the exacerbation of hypertension required discontinuation of bupropion treatment. Patients should quit tobacco smoking prior to initiating the nicotine therapy in the bupropion-NTS combination regimen to reduce the risk of unwanted cardiac side effects. Close blood pressure monitoring is recommended.
Patients who are taking bupropion should not self-treat with OTC nicotine products; the bupropion-NTS combination should only be used under the prescription and advice of a health-care prescriber. When used as monotherapy, patients should schedule to stop tobacco smoking during the second week of taking bupropion. When bupropion is used for smoking cessation, it should be noted that cessation of tobacco smoking may result in elevated serum concentrations of some drugs that are hepatically metabolized, such as theophylline and warfarin due to lowered induction of hepatic oxidative microsomal enzymes tobacco smoke induces hepatic enzymes.
Downward dosage adjustments of such drugs and more frequent monitoring may be required during smoking cessation. Bupropion has been used in children and adolescents for the treatment of attention-deficit hyperactivity disorder ADHD. Sudden unexplained death has occurred in adults and pediatric patients receiving stimulants at standard dosages for ADHD.
Although bupropion is not a stimulant medication, the American Heart Association recommends conducting a detailed patient and family history and physical examination prior to initiating any ADHD pharmacologic treatment, and obtaining a baseline electrocardiogram ECG is a reasonable addition to the initial evaluation.
Once the medication is started, a repeat ECG may be helpful if the original ECG was obtained before the child was 12 years old, if cardiac symptoms develop, or there is a change in family history. If a child or adolescent has any significant findings on physical examination, ECG, or family history, consult a pediatric cardiologist before initiating the medication. Of roughly 6, patients in bupropion sustained-release studies for both smoking cessation and depression, were 65 and over and 47 were 75 and over.
Several hundred geriatric patients 65 years and older have also been studied in depression with the immediate-release formulation. Both initial and maintenance bupropion doses should be reduced in geriatric patients if hepatic or renal impairment or debilitating disease is present; multiple-dose pharmacokinetic studies have indicated the elderly may be at risk for bupropion and metabolite accumulation.
It may be useful to monitor renal function in the elderly. Bupropion may also cause weight loss which may be significant for elderly or otherwise debilitated patients.
According to OBRA, follow the recommended duration of therapy per pertinent literature for the condition being treated, including clinical practice guidelines. All residents being treated for depression with any antidepressant should be monitored closely for worsening of depression and suicidal behavior or thinking, especially during initiation of therapy and during dose changes. Antidepressants may cause dizziness, nausea, diarrhea, anxiety, nervousness, insomnia, sedation, weight gain, anorexia, or increased appetite.
Many of these effects can increase the risk of falls. Bupropion may increase seizure risk and activity in susceptible individuals. Before discontinuation, taper bupropion to avoid a withdrawal syndrome. Concurrent use of two or more antidepressants may increase the risk of side effects; in such cases, there should be documentation of expected benefits that outweigh the associated risks and monitoring for an increase in side effects.
Monitoring should consist of a review for continued need at least quarterly, and documentation of the rationale for continuation. When the drug is being used to manage behavior, stabilize mood, or treat a psychiatric disorder, the facility should attempt to taper the medication as outlined in the OBRA guidelines, unless a taper is clinically contraindicated. Patients should be warned to use caution when driving or operating machinery or performing other tasks that require mental alertness until they know how bupropion will affect them.
Some patients have reported lower alcohol tolerance during treatment with bupropion; advise patients that the consumption of alcohol should be minimized or avoided; avoid ethanol intoxication. Caution is recommended when prescribing bupropion to patients with closed-angle glaucoma.
The pupillary dilation that can occur with antidepressants may precipitate a closed-angle glaucoma attack in patients with anatomically narrow angles who do not have a patent iridectomy. An acute attack of closed-angle glaucoma is considered a medical emergency because the increased intraocular pressure is rapid and severe, and may quickly result in blindness if left untreated. It is generally recommended to avoid abrupt discontinuation of antidepressants.
If discontinuing bupropion, the medication should be tapered as rapidly as possible, but with recognition that abrupt discontinuation can also cause adverse symptoms. Because Forfivo XL is only available in a mg tablet, the manufacturer recommends using another bupropion formulation for tapering the dose prior to discontinuation.
Laboratory test interference has been reported with bupropion use. False-positive urine immunoassay screening tests for amphetamines have been reported in patients taking bupropion. The false-positive result is due to lack of specificity of some screening tests. False-positive test results may result even following discontinuation of bupropion therapy. Excessive use of psychostimulants, including caffeine, is associated with an increased seizure risk and may increase this risk during the concurrent use of bupropion.
Carefully consider a patient's caffeine intake from all sources, including medicines. Monitor for irritability, tremor, increased blood pressure, insomnia and seizures.
Many non-prescription medicines and weight loss aids may contain caffeine and patients should read labels carefully. Examples of foods and beverages containing caffeine include coffee, teas, colas, energy drinks, chocolate, and some herbal or dietary supplements.
Patients should be advised to limit excessive caffeine intake during bupropion therapy. Acetaminophen; Caffeine: Moderate Bupropion is associated with a dose-related risk of seizures. Acetaminophen; Caffeine; Dihydrocodeine: Moderate Bupropion is associated with a dose-related risk of seizures. Moderate Concomitant use of dihydrocodeine with bupropion may increase dihydrocodeine plasma concentrations, but decrease the plasma concentration of the active metabolite, dihydromorphine, resulting in reduced efficacy or symptoms of opioid withdrawal.
If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage increase of dihydrocodeine until stable drug effects are achieved. Discontinuation of bupropion could decrease dihydrocodeine plasma concentrations and increase dihydromorphine plasma concentrations resulting in prolonged opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
If bupropion is discontinued, monitor the patient carefully and consider reducing the opioid dosage if appropriate. Bupropion is a strong inhibitor of CYP2D6. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: Moderate Bupropion is associated with a dose-related risk of seizures.
Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: Moderate Bupropion is associated with a dose-related risk of seizures. Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Excessive use of psychostimulants, including non-prescription stimulants and weight loss medications, is associated with an increased seizure risk; seizures may be more likely to occur in these patients during concurrent use of bupropion.
Patients should be closely monitored if these combinations are necessary. Acetaminophen; Codeine: Moderate Concomitant use of codeine with bupropion may increase codeine plasma concentrations, but decrease the plasma concentration of the active metabolite, morphine, resulting in reduced efficacy or symptoms of opioid withdrawal. It is recommended to avoid this combination when codeine is being used for cough. If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage increase of codeine until stable drug effects are achieved.
Discontinuation of bupropion could decrease codeine plasma concentrations and increase morphine plasma concentrations resulting in prolonged opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Acetaminophen; Dextromethorphan; Guaifenesin; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures.
Acetaminophen; Dextromethorphan; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Acetaminophen; Hydrocodone: Moderate Concomitant use of hydrocodone with bupropion may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
It is recommended to avoid this combination when hydrocodone is being used for cough. If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of hydrocodone until stable drug effects are achieved. Discontinuation of bupropion could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone. If bupropion is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate.
Hydrocodone is a substrate for CYP2D6. Plasma concentrations of opiate agents metabolized by CYP2D6 such as oxycodone may be increased if bupropion is added. Dosage reductions in these agents may be needed. Conversely, if bupropion therapy is discontinued, dosages of these agents may need to be adjusted upward in some patients.
Excessive use of opioid agonists e. Dosage reductions of pentazocine may be needed. Conversely, if bupropion therapy is discontinued, dosages of pentazocine may need to be adjusted upward in some patients.
Plasma concentrations of opiate agents metabolized by CYP2D6 such as propoxyphene may be increased if bupropion is added. Acetaminophen; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Acetazolamide: Moderate It should be noted that when anticonvulsants are used for the purpose of treating epilepsy versus use in mood disorders or neuropathic pain or other non-epilepsy conditions , that bupropion should not be used by patients with a preexisting seizure disorde; this represents a disease-drug interaction, and not a drug-drug interaction per se.
Bupropion may be combined with anticonvulsant treatments with caution when an anticonvulsant is used for non-epilepsy conditions. Addiive CNS effects are possible, and the patient may feel dizzy, drowsy or more tired when taking these drugs together. Acrivastine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures.
Alfentanil: Moderate If concomitant use of alfentanil and bupropion is warranted, monitor patients for the emergence of serotonin syndrome. Discontinue all serotonergic agents and initiate symptomatic treatment if serotonin syndrome occurs. The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome. Although specific recommendations are not available from the manufacturer, it would be prudent to avoid these drugs in patients taking alosetron.
Amantadine: Major Use caution when concurrently administering bupropion and amantadine; if concurrent use is necessary, low initial dosing and slow dosage titration of bupropion should be considered. Both bupropion and amantadine have dopamine agonist effects, and coadministration may result in additive CNS dopaminergic effects.
Reported adverse reactions have included neurologic side effects such as restlessness, agitation, gait disturbance, vertigo, and dizziness; some patients have required hospitalization. In reported cases, discontinuation of the drugs resulted in symptom resolution. Amifampridine: Major Carefully consider the need for concomitant treatment with bupropion and amifampridine, as coadministration may increase the risk of seizures. Consider alternatives to bupropion.
If use together is medically necessary, closely monitor patients for seizure activity. Seizures have been observed in patients without a history of seizures taking amifampridine at recommended doses. Bupropion is known to have a dose-dependent risk for seizures. The manufacturer of bupropion warns of using any TCAs with bupropion due to the potential for increased risk of seizures from the lowering of seizure threshold.
Bupropion-induced elevations in both imipramine and desipramine plasma concentrations may occur. TCA half-lives have increased in pharmacokinetic studies. The anticholinergic effects of bupropion may also be additive with those of the TCAs. Prolonged seizure activity has been reported following the combined use clomipramine and bupropion. The manufacturer recommends low initial dosing and slow dosage titration if these drugs must be used concurrently; the patient should be closely monitored.
Amobarbital: Moderate Bupropion may interact with drugs that induce hepatic microsomal isoenzyme function via CYP2B6 such as the barbiturates. While not systematically studied, these drugs may induce the metabolism of bupropion and may decrease bupropion exposure. If bupropion is used concomitantly with a CYP inducer, it may be necessary to increase the dose of bupropion, but the maximum recommended dose should not be exceeded. Advise patients that until they are reasonably certain that the combination does not adversely affect their performance, they should refrain from driving an automobile or operating complex, hazardous machinery.
Amoxapine: Major Concurrent administration of amoxapine with bupropion should be undertaken only with extreme caution due to the potential for increased risk of seizures from the lowering of seizure threshold. In addition, bupropion inhibits the hepatic isozyme CYP2D6 and thus may reduce the clearance of amoxapine leading to a potential for increased Cmax, AUC and half-life.
Amoxapine appears to be metabolized via CYP2D6. Low initial dosing and gradual dose increases of both drugs should be employed. If bupropion is added to a regimen of a patient already receiving amoxapine, the need to reduce the amoxapine dosage should be considered.
Amphetamine: Major Bupropion is associated with a dose-related risk of seizures. Amphetamine; Dextroamphetamine Salts: Major Bupropion is associated with a dose-related risk of seizures. Amphetamine; Dextroamphetamine: Major Bupropion is associated with a dose-related risk of seizures. Anticonvulsants: Moderate Bupropion should not be used by patients with a preexisting seizure disorder because it may lower the seizure threshold.
Bupropion may also interact pharmacokinetically with some anticonvulsant drugs that induce hepatic microsomal isoenzyme function. Aripiprazole: Major Because aripiprazole is partially metabolized by CYP2D6, the manufacturer recommends that the oral aripiprazole dose be reduced to one-half of the usual dose in patients receiving strong inhibitors of CYP2D6 such as bupropion. Closely monitor for evidence of aripiprazole adverse events.
Additionally, bupropion is associated with a dose-related risk of seizure; antipsychotics may increase this risk. In adults receiving mg or mg of Abilify Maintena, dose reductions to mg or mg, respectively, are recommended if a strong CYP2D6 inhibitor is used for more than 14 days. Adults receiving mg or mg of Aristada every 4 weeks should have their Aristada dose reduced to the next lower strength if a strong CYP2D6 inhibitor is used for more than 14 days.
For patients receiving Aristada mg every 6 weeks or 1, mg every 2 months, reduce the dose to mg every 4 weeks.
No dosage adjustment is necessary in patients taking mg of Aristada, if tolerated. Avoid use of combination therapy with a strong CYP2D6 inhibitor and a strong CYP3A4 inhibitor for more than 14 days in patients receiving mg, mg, or 1, mg of Aristada; no dosage adjustment is necessary in patients taking mg of Aristada, if tolerated. Armodafinil: Major Bupropion is associated with a dose-related risk of seizures.
Asenapine: Major Bupropion is associated with a dose-related risk of seizures. Extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as antipsychotics. The manufacturer of bupropion recommends low initial dosing and slow dosage titration if this combination must be used; the patient should be closely monitored. Moderate Bupropion may interact with drugs that induce hepatic microsomal isoenzyme function via CYP2B6 such as the barbiturates.
Moderate Concomitant use of codeine with bupropion may increase codeine plasma concentrations, but decrease the plasma concentration of the active metabolite, morphine, resulting in reduced efficacy or symptoms of opioid withdrawal. Aspirin, ASA; Carisoprodol; Codeine: Moderate Concomitant use of codeine with bupropion may increase codeine plasma concentrations, but decrease the plasma concentration of the active metabolite, morphine, resulting in reduced efficacy or symptoms of opioid withdrawal.
Atazanavir; Cobicistat: Moderate Caution is warranted when cobicistat is administered with bupropion as there is a potential for elevated cobicistat concentrations.
Atomoxetine: Major Dosage reduction of atomoxetine is recommended in patients receiving bupropion due to the potential for increased atomoxetine exposure and related adverse effects. In children and adolescents up to 70 kg receiving bupropion, atomoxetine should be initiated at 0. Coadministration of a strong CYP2D6 inhibitor and atomoxetine in extensive metabolizers of CYP2D6, increased atomoxetine steady-state plasma concentrations by approximately 6 to 8-fold.
This increase is similar to exposures observed in poor metabolizers. Concurrent use of a strong CYP2D6 inhibitor with atomoxetine in poor metabolizers is not expected to increase atomoxetine exposure. Atropine: Moderate The anticholinergic effects of atropine may be enhanced when combined with other drugs with moderate to significant anticholinergic effects including bupropion. Clinicians should note that antimuscarinic effects might be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation.
Additive drowsiness may also occur. Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate: Contraindicated Due to an increased risk of hypertensive reactions, treatment initiation with bupropion is contraindicated in patients currently receiving intravenous methylene blue.
If urgent psychiatric treatment is required, interventions other than bupropion e. Conversely, in patients receiving bupropion and requiring urgent treatment with intravenous methylene blue, bupropion should be discontinued immediately and methylene blue therapy initiated only if acceptable alternatives are not available and the potential benefits of methylene blue outweigh the risks.
The patient should be monitored for hypertensive reactions for two weeks or until 24 hours after the last dose of methylene blue, whichever comes first. Bupropion may be re-initiated 24 hours after the last dose of methylene blue. It is not known if administration of methylene blue by other routes e.
Moderate Additive anticholinergic effects may be seen when hyoscyamine is used concomitantly with bupropion. Additive drowsiness may occur. Moderate The anticholinergic effects of atropine may be enhanced when combined with other drugs with moderate to significant anticholinergic effects including bupropion. Atropine; Difenoxin: Moderate The anticholinergic effects of atropine may be enhanced when combined with other drugs with moderate to significant anticholinergic effects including bupropion.
Atropine; Edrophonium: Moderate The anticholinergic effects of atropine may be enhanced when combined with other drugs with moderate to significant anticholinergic effects including bupropion. Azelastine; Fluticasone: Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids.
Low initial dosing and slow dosage titration of bupropion is recommended if these combinations must be used; the patient should be closely monitored. Barbiturates: Moderate Bupropion may interact with drugs that induce hepatic microsomal isoenzyme function via CYP2B6 such as the barbiturates.
Beclomethasone: Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids. Belladonna Alkaloids; Ergotamine; Phenobarbital: Moderate Bupropion may interact with drugs that induce hepatic microsomal isoenzyme function via CYP2B6 such as the barbiturates.
Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate: Contraindicated Due to an increased risk of hypertensive reactions, treatment initiation with bupropion is contraindicated in patients currently receiving intravenous methylene blue.
Benzphetamine: Major The risk of seizures from the use of bupropion may be increased with concomitant use of CNS stimulants and anorectics that may induce seizures, including benzphetamine. Concurrent use is not recommended. Extreme caution and close clinical monitoring is recommended if these agents must be used together. Benztropine: Moderate Additive anticholinergic effects may be seen when benztropine is used concomitantly with other drugs that possess anticholinergic properties, such as bupropion.
Clinicians should note that anticholinergic effects might be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation.
Betamethasone: Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids. Bethanechol: Moderate Bupropion exhibits moderate anticholinergic properties.
Avoid co-use when possible since the effects of bethanechol, a cholinergic agonist, may be diminished. If co-use is necessary, monitor for the intended clinical response. If these agents are used in combination, the patient should be carefully monitored for brexpiprazole-related adverse reactions.
Additionally, bupropion is associated with a dose-related increase in seizures; antipsychotics may increase this risk. It should be noted that no dosage adjustment is needed in patients taking a strong CYP2D6 inhibitor who are receiving brexpiprazole as adjunct treatment for major depressive disorder because CYP2D6 considerations are already factored into general dosing recommendations. Brimonidine; Timolol: Minor Monitor for an increased incidence of timolol-related adverse effects if bupropion and timolol are used concomitantly.
Coadministration of bupropion and timolol may result in increased plasma concentrations of timolol. Bupropion and hydroxybupropion, the major active metabolite, are inhibitors of CYP2D6 in vitro. Timolol is a CYP2D6 substrate. Brompheniramine; Guaifenesin; Hydrocodone: Moderate Concomitant use of hydrocodone with bupropion may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
Brompheniramine; Hydrocodone; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Moderate Concomitant use of hydrocodone with bupropion may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
Brompheniramine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Brompheniramine; Pseudoephedrine; Dextromethorphan: Major Bupropion is associated with a dose-related risk of seizures. Budesonide: Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids.
Budesonide; Formoterol: Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids.
Budesonide; Glycopyrrolate; Formoterol: Moderate Additive anticholinergic effects may be seen when glycopyrrolate is used concomitantly with bupropion. Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids.
Buprenorphine: Moderate If concomitant use of buprenorphine and bupropion is warranted, monitor patients for the emergence of serotonin syndrome. Buprenorphine; Naloxone: Moderate If concomitant use of buprenorphine and bupropion is warranted, monitor patients for the emergence of serotonin syndrome. Butabarbital: Moderate Bupropion may interact with drugs that induce hepatic microsomal isoenzyme function via CYP2B6 such as the barbiturates. Butalbital; Acetaminophen: Moderate Bupropion may interact with drugs that induce hepatic microsomal isoenzyme function via CYP2B6 such as the barbiturates.
Butalbital; Acetaminophen; Caffeine: Moderate Bupropion is associated with a dose-related risk of seizures. Butalbital; Acetaminophen; Caffeine; Codeine: Moderate Bupropion is associated with a dose-related risk of seizures. Caffeine: Moderate Bupropion is associated with a dose-related risk of seizures. Caffeine; Sodium Benzoate: Moderate Bupropion is associated with a dose-related risk of seizures.
Calcium, Magnesium, Potassium, Sodium Oxybates: Major Use extreme caution when coadministering bupropion with other drugs that lower the seizure threshold, such as sodium oxybate.
The risk of seizures with bupropion is dose related and is also related to patient factors, clinical situations, and concomitant medications that lower the seizure threshold. Consider these risks before initiating treatment If used together, use low initial doses of bupropion and increase the dose gradually. Cannabidiol: Moderate Consider a dose adjustment of bupropion when coadministered with cannabidiol.
Carbamazepine: Moderate Bupropion should not be used by patients with a preexisting seizure disorder because it may lower the seizure threshold. Carbamazepine induces hepatic enzymes and may lower bupropion exposure. Bupropion is a sensitive substrate of CYP2B6, and carbamazepine is a potent inducer for this enzyme.
Monitor for signs of reduced bupropion efficacy during use together. Also monitor for any changes in seizure status if carbamazepine is used to treat seizures. Carbetapentane; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Carbidopa; Levodopa: Major Use bupropion cautiously in patients taking levodopa or combination drugs containing levodopa e.
Both drugs are dopamine agonists; cumulative effects may result in central nervous system CNS toxicity. Adverse reactions reported with coadministration have included restlessness, agitation, tremor, ataxia, gait disturbance, vertigo, and dizziness. If levodopa is used concurrently, low initial dosing and slow dosage titration of bupropion may be warranted. Carbidopa; Levodopa; Entacapone: Major Use bupropion cautiously in patients taking levodopa or combination drugs containing levodopa e.
Carbinoxamine; Dextromethorphan; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Carbinoxamine; Hydrocodone; Phenylephrine: Moderate Concomitant use of hydrocodone with bupropion may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
Carbinoxamine; Hydrocodone; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Carbinoxamine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Cariprazine: Major Bupropion is associated with a dose-related risk of seizures. Carvedilol: Minor Monitor for an increased incidence of carvedilol-related adverse effects if bupropion and carvedilol are used concomitantly. Coadministration of bupropion and carvedilol may result in increased plasma concentrations of carvedilol.
Carvedilol is a CYP2D6 substrate. Cenobamate: Major Increase the dosage of bupropion as needed when coadministered with cenobamate due to the potential for reduced efficacy of bupropion. Cetirizine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures.
Inhibitors of this isoenzyme, like bupropion, would be expected to lead to an increase in cevimeline plasma concentrations. Chlophedianol; Dexchlorpheniramine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures.
Chlordiazepoxide; Clidinium: Moderate Bupropion exhibits moderate anticholinergic effects. Clinicians should consider this when using antimuscarinics and other medications with anticholinergic activity in combination with bupropion. Chlorpheniramine; Codeine: Moderate Concomitant use of codeine with bupropion may increase codeine plasma concentrations, but decrease the plasma concentration of the active metabolite, morphine, resulting in reduced efficacy or symptoms of opioid withdrawal.
Chlorpheniramine; Dextromethorphan; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Chlorpheniramine; Dihydrocodeine; Phenylephrine: Moderate Concomitant use of dihydrocodeine with bupropion may increase dihydrocodeine plasma concentrations, but decrease the plasma concentration of the active metabolite, dihydromorphine, resulting in reduced efficacy or symptoms of opioid withdrawal.
Chlorpheniramine; Dihydrocodeine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures.
Chlorpheniramine; Hydrocodone: Moderate Concomitant use of hydrocodone with bupropion may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
Chlorpheniramine; Hydrocodone; Phenylephrine: Moderate Concomitant use of hydrocodone with bupropion may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Chlorpheniramine; Hydrocodone; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Chlorpheniramine; Ibuprofen; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures.
Chlorpheniramine; Pseudoephedrine: Major Bupropion is associated with a dose-related risk of seizures. Chlorpromazine: Major Bupropion is associated with a dose-related risk of seizures and may have an additive effect with phenothiazines on lowering the seizure threshold. Low initial dosing and slow titration is recommended if this combination must be used. In addition, bupropion is a strong inhibitor of CYP2D6.
Dosage reductions of chlorpromazine, a CYP2D6 substrate, may be needed during coadministration with bupropion. Increased serum concentrations of chlorpromazine may result in QT prolongation, somnolence, anticholinergic effects, or orthostasis. Ciclesonide: Moderate Because bupropion is associated with a dose-related risk of seizures, extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as systemic corticosteroids.
We strive to use primary sources and refrain from using tertiary references. This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice.
Always talk to your doctor about the risks and benefits of any treatment. Insider tips, early access and more. Top Treatments. Top Conditions Erectile Dysfunction. Mental Health.
Wellbutrin Dosage Guide for Depression and Anxiety. Anxiety By contrast, anxiety is a collection of mood disorders representing intense feelings of anxiety, unease, or panic, according to the National Institute of Mental Health. What is Wellbutrin? Now that we know more about what Wellbutrin treats, we need to take a look at Wellbutrin itself. Chris Aiken, M. Psychiatric Times. Updated Apr In: StatPearls Internet.
Trivedi, M. Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?. The Journal of clinical psychiatry, 62 10 , — National Library of Medicine. Sertraline: MedlinePlus Drug Information. There are several reasons: Not everyone taking stimulant medication experiences a significant reduction of his or her ADHD symptoms.
In these cases, adding Wellbutrin, which enhances the action of dopamine and norepinephrine in the brain, might help. Patients taking stimulant medications sometimes experience negative side effects. The action of Wellbutrin is different than that of stimulant medications, so some patients may experience fewer negative side effects on Wellbutrin. The majority of ADHD patients also have at least one comorbid condition. Co-existing conditions, such as depression and anxiety , are more than common — they are the norm for patients with ADHD.
Adding an antidepressant, such as Wellbutrin, can sometimes help in treating and minimizing these symptoms. An underlying medical or psychiatric condition may make the prescription of a stimulant medication less than ideal. For example, a heart condition, sleep disorders, tic disorder, a history of dependency, and some other psychiatric conditions such as mood disorders may preclude a patient from safely taking a stimulant medication.
Common Side Effects of Wellbutrin dizziness low appetite blurry vision agitation, increased anxiety difficulty sleeping headache dry mouth nausea or vomiting constipation sweating muscle twitching, restlessness Important Information About Taking Wellbutrin for ADHD It can take some time to realize the full benefit of Wellbutrin.
In contrast to the quick onset of stimulant medication, it may take patients approximately 3 to 7 days to notice any benefits of Wellbutrin. It may also take several weeks for a prescriber and patient to find the most effective therapeutic dose.
Once the dose has been adjusted, it can take an additional weeks for a patient to experience the full benefit of Wellbutrin. While the dosage is being determined, signs that the medication is working are an improved mood, increased appetite, and better sleep. Patients who want to stop taking Wellbutrin should discuss this with their physician. Patients may experience irritability when stopping Wellbutrin abruptly. Wellbutrin is not considered safe to take during pregnancy or while breastfeeding.
Patients who are pregnant or planning to become pregnant should discuss medications with their clinician.
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